APIs
Yamasa manufactures small molecular active pharmaceutical ingredients (APIs) of nucleic acid related compounds. Yamasa provides APIs for new drugs at all stage from R&D to commercial, and for generic drugs.
In addition to the listed products which are examples of APIs for generic drugs, we are manufacturing other APIs.
Mizoribine
Mizoribine is an immunosuppressive drug which is applied for prevention of renal transplant rejection, lupus nephritis, and rheumatoid arthritis.
Vidarabine
Vidarabine is an anti-virus drug which is applied for herpes simplex and herpes zoster.
| Product name | Synonym | Structure |
|---|
| Mizoribine | Mizoribine |  |
| Vidarabine | Vidarabine |  |
Oligonucleotides
Therapeutic oligonucleotides are composed of modified nucleoside monomers. Yamasa provides the modified monomers and offers custom synthesis of oligomers. In addition to existing monomers including LNA amidites, Yamasa can collaborate in developmnt of new monomers.
| Product name | Synonym | Structure |
|---|
| LNA-T Phosphoramidite | LNA-T Phosphoramidite |  |
| LNA-A(Bz) Phosphoramidite | LNA-A(Bz) Phosphoramidite |  |
| LNA-G(dmf) Phosphoramidite | LNA-G(dmf) Phosphoramidite |  |
| LNA-5-MeC(Bz) Phosphoramidite | LNA-5-MeC(Bz) Phosphoramidite |  |
Materials used for mRNA synthesis
Yamasa provides the materials used for synthesis of mRNA. Yamasa has been providing high quality Pseudouridine used for mRNA COVID-19 vaccines in commercial scale.
| Product name | Synonym | Structure |
|---|
| 5-Methylcytidine 5'-triphosphate, solution | 5-Me-CTP |  |
| 1-Methylpseudouridine | 1-Me-Pseudouridine |  |
| 1-Methylpseudouridine 5'-triphosphate, solution | 1-Me-Pseudo-UTP |  |
| Pseudouridine | Pseudouridine |  |
| Pseudouridine 5'-triphosphate, solution | Pseudo-UTP |  |
Chemicals
Yamasa offers nucleic acid related compounds as pharmaceutical intermediates and industrial products obtained by chemical or enzymatic synthesis of each nucleotide.
Nucleotides are used as intermediates of APIs, food additives, and cosmetic ingredients. These days, nucleotides are globally used as key ingredients for infant formula. Yamasa manufactures high quality nucleotides for food additives under ISO 9001.
| Product name | Synonym | Structure |
|---|
| Adenosine | Adenosine |  |
| Adenosine 5'-monophosphate, disodium salt | 5'-AMP, 2Na |  |
| Adenosine 5'-monophosphate, free acid | 5'-AMP, free |  |
| Cytidine | Cytidine |  |
| Cytidine 5'-diphosphate, trisodium salt | 5'-CDP, 3Na |  |
| Cytidine 5'-monophosphate, disodium salt | 5'-CMP, 2Na |  |
| Cytidine 5'-monophosphate, free acid | 5'-CMP, free |  |
| 2'-Deoxyadenosine 5'- triphosphate, solution | dATP |  |
| 2'-Deoxycytidine 5'- triphosphate, solution | dCTP |  |
| 2'-Deoxyguanosine 5'- triphosphate, solution | dGTP |  |
| 2'-Deoxythymidine 5'- triphosphate, solution | dTTP |  |
| Guanosine 5'-monophosphate, disodium salt | 5'-GMP, 2Na |  |
| Inosine 5'-diphosphate, trisodium salt | 5'-IDP, 3Na |  |
| Inosine 5'-monophosphate, disodium salt | 5'-IMP, 2Na |  |
| Uridine | Uridine |  |
| Uridine 5'-diphosphate, disodium salt | 5'-UDP, 2Na |  |
| Uridine 5'-monophosphate, disodium salt | 5'-UMP, 2Na |  |
| Xanthosine | Xanthosine |  |
| 3’-Phosphoadenosine 5’-Phosphosulfate Sodium Salt | PAPS |  |
Sugar nucleotides
Sugar nucleotides are the substances made of nucleotide and sugar. Sugar nucleotides are the activated forms of monosaccharides acting as glycosyl donors.Sugar nucleotides play a role as substrates in the enzymatic synthesis of oligosaccharides. For example, sugar nucleotides are used for glycosylation modification to biopharmaceutical.
Yamasa supplies 8 types of sugar nucleotides with high quality which can be used for glycoengineering by enzymatic synthesis technology.
| Product name | Synonym | Structure |
|---|
| Cytidine 5'-monophospho-N-acetylneuraminic acid disodium salt | CMP-NeuAc, 2Na |  |
| Guanosine 5'-diphosphofucose, disodium salt | GDP-Fuc, 2Na |  |
| Guanosine 5'-diphospho-D-mannose, disodium salt | GDP-Man,2Na |  |
| Uridine 5'-diphospho-N-acetylglucosamine, disodium salt | UDP-GlcNAc, 2Na |  |
| Uridine 5'-diphospho-N-acetylgalactosamine, disodium salt | UDP-GalNAc, 2Na |  |
| Uridine 5'-diphosphogalactose, disodium salt | UDP-Gal, 2Na |  |
| Uridine 5'-diphosphoglucose, disodium salt | UDP-Glc, 2Na |  |
| Uridine 5'-diphosphoglucuronate, trisodium salt | UDP-GlcUA, 3Na |  |
Adjuvants
STING ligands typified by cyclic di-AMP are actively studied for use in various vaccine therapies including cancer immunotherapy. Yamasa can supply high-quality cyclic di-AMP with controlled endotoxin level. Yamasa also supply Poly(I:C), an excellent TLR3-acting adjuvant, with controlled chain-length.
| Product name | Synonym | Structure |
|---|
| 3’,5’-Cyclic diadenylic acid, disodium salt | c-di-AMP, 2Na |  |
| 3',5'-Cyclic diguanylic acid | c-di-GMP |  |
| Polycytidylate, sodium salt | Poly (C), Na |  |
| Polyinosinate, sodium salt | Poly (I), Na |  |
| Polyinosinate Polycytidylate, sodium salt | Poly (I)･Poly（C), Na |  |
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