Custom synthesis at laboratory
Yamasa synthesize candidate compounds for new drugs required from discovery to early clinical stage at laboratory. Utilizing our experience of drug discovery research for anticancer drugs and antivirus drugs of nucleic acid related compounds, Yamasa synthesizes various nucleic acid related compounds whose sugar, nucleobase or phosphate is modified.
Not only in custom synthesis of small molecular nucleic acid related compounds, Yamasa can collaborate in development of monomers for oligonucleotides.
Flow of custom synthesis
Examples
Examples of sugar modification
Examples of base modification
Examples of phosphoras modification
References
- 1) Nucleosides & Nucleotides, 15, 305 (1996)
- 2) Nucleosides, Nucleotides and Nucleic Acids, 28, 1117 (2009)
- 3) Nucleosides & Nucleotides, 14, 427 (1995)
- 4) Bioorg. Med. Chem. Lett., 20, 6013 (2010)
- 5) Tetrahedron, 53, 13315 (1997)
- 6) J. Med. Chem., 43, 4516 (2000)
- 7) Nucleosides, Nucleotides and Nucleic Acids, 23, 671 (2004)
- 8) J. Org. Chem., 62, 3140 (1997)
- 9) Bioorg. Med. Chem., 8, 1545 (2000)
- 10) Tetrahedron Lett., 47, 591 (2006)
- 11) Tetrahedron Lett., 44, 8605 (2003)
- 12) Antiviral Chem. Chemother., 14, 161 (2004)
- 13) Bioorg. Med. Chem. Lett., 22, 3072 (2014)
- 14) Nucleosides & Nucleotides, 19, 955 (2000)
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